Phenylbenzisoxazoles and aminopyrimidines

RESEARCH

Protein Kinase Inhibitor Development

FGFR1 Inhibitors

Phenylbenzisoxazoles and aminopyrimidines

Phenylbenzisoxazoles and aminopyrimidines were also found from virtual screening. Search for analogues of these inhibitors reveal the most active compounds with an IC₅₀of 5 and 4 mM, respectively. These compounds serve as starting points for further optimization.

Figure 1. Phenylbenzisoxazole and aminopyrimidine inhibitors of FGFR1.

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