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Structure-based discovery of novel flavonol inhibitors of human protein kinase CK2

We have published new scientific paper on CK2 inhibitors. 

Abstract: Serine/threonine protein kinase CK2 controls vast variety of fundamental processes in cell life; however...

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The new class of the human ASK1 inhibitors has been identified by our scientists

Apoptosis signal-regulating kinase 1 (ASK1) has recently emerged as an attractive therapeutic target for the treatment of cardiac and neurodegenerative disorders. The selective inhibitors...

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The new class of potent ATP-competitive inhibitors of the human protein kinase CK2 has been identified

A novel series of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids has been synthesized and tested in vitro towards human protein kinase CK2. It was revealed that the...

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VI International Conference on Protein Kinase CK2

Scientists from Department of Medicinal Chemistry participated in the VI International Conference on Protein Kinase CK2 (07-10 September, 2010, Cologne, Germany). Their oral presentation...

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Our research:

FGFR1 Inhibitors
Quinazolines Image
Quinazolines is another known class of RTK inhibitors that is widely...



 

ASK1 Inhibitors
Evaluation of 2-Thioxo-thiazolidin-4-ones Derivatives as Inhibitors of ASK1 Image
In order to discover novel ASK1 inhibitors we have performed screening program,...



 

CK2 Inhibitors
4-aminothieno[2,3-d]pyrimidines Image
Novel CK2 inhibitors among 4-aminothieno[2,3-d]pyrimidines have been...



 

Fluorescent Probes
Design of fluorescent dyes for biomedical applications Image
Search and development of novel highly efficient fluorescent probes for biology...



 

Molecular Design
Molecular Design Image
Molecular Design Laboratory of Medicinal Chemistry Department carry out...



 

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